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無創(chuàng)傷肺功能檢測 Non-invasive Airway Mechanics

本系統(tǒng)提供長期跟蹤研究的另一種選擇，即可對同一動物進行多次跟蹤檢測。實驗動物處于清醒但不能自由活動的狀態(tài)。該系統(tǒng)使用雙腔式體積描記器，對動物的頭部和胸部氣流分別進行測定并計算得出比氣道阻力（ｓＲａｗ）和比氣道傳導(dǎo)率（ｓＧａｗ）?？筛鶕?jù)需要加配霧化給藥系統(tǒng)。

產(chǎn)品特點：

? 可同時觀測多只動物，并適合長期跟蹤研究；清潔，完整的設(shè)計。使用*少的管線連接一個平臺就可同時監(jiān)測多達四只動物；

? SRaw和SGaw參數(shù)與有創(chuàng)方式測定的氣道阻力具有高度相關(guān)性；

? 動物實驗準備較全身體積描記法復(fù)雜；

? 一個平臺就可應(yīng)用于小鼠，大鼠和豚鼠-只需搭配不同的動物腔室即可；

? 自動感應(yīng)物種種類和調(diào)整分析設(shè)置；

The EMMS non-invasive airway mechanics system uses a classic Pennock style double-chamber plethysmograph to measure nasal and thoracic flow. The animal is placed in a double-chamber plethysmograph (eg. PLY 230 for guinea pig)， and is restrained in the chamber with a rubber neck collar. This neck collar also provides an airtight seal between the thoracic and nasal chambers. Flow in the two chambers is measured across two pneumotachographs in the plethysmograph wall. A bias flow air supply is used to prevent build-up of CO2 in the plethysmograph， and may also be used to pull aerosol through the nasal chamber.

Parameters Measured

· Specific Airway Resistance

· Specific Airway Conductance

· Tidal Volume

· Minute Volume

· Time of Inspiration

· Time of Expiration

· Peak Expiratory Flow

· Peak Inspiratory Flow

· Respiratory Rate

· Explanations and more parameters

Features

· Up to 8 animals monitored simultaneously

· Completely non-invasive

· No anaesthesia required

· Aerosol can be administered via the nasal chamber

Uses

· Chronic studies

· Suitable for long-term measurements

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